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In these cases, your doctor may decide that you need a higher dose.Adverse ReactionsVardenafil is metabolized predominantly by the hepatic enzyme CYP3A4, with contribution from the CYP3A5 and CYP2C isoforms. The major circulating metabolite, M1, results from desethylation at the piperazine moiety of vardenafil. M1 is subject to further metabolism. The plasma concentration of M1 is approximately 26% that of the parent compound. This metabolite shows a phosphodiesterase selectivity profile similar to that of vardenafil and an in vitro inhibitory potency for PDE5 28% of that of vardenafil. Therefore, M1 accounts for approximately 7% of total pharmacologic activity.
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Sadly, thats not happening with Johnson or with health insurers, because of a simple, age-old double standard. Men supposedly need sex due to biological urges; impotence is considered a medical disease, hence its cure should be funded. Women, thought to have lower sex drives, are assumed to bear the reproductive risk (we play, we pay). Since pregnancy is not a "disease" and reproductive control is considered "optional" or "recreational," health insurers do not consider themselves bound to cover contraceptives.
viagra no prescription ?VIAGRA was administered to over 3700 patients (aged 19-87 years) during pre-marketing clinical trials worldwide. Over 550 patients were treated for longer than one year.
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