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HIV Protease inhibitor — Ritonavir (500 mg or 600 mg twice daily at steady state), an inhibitor of CYP3A4, CYP2C9, CYP2C19, and CYP2D6, increased tadalafil 20-mg single-dose exposure (AUC) by 32% with a 30% reduction in Cmax, relative to the values for tadalafil 20 mg alone. Ritonavir (200 mg twice daily), increased tadalafil 20-mg single-dose exposure (AUC) by 124% with no change in Cmax, relative to the values for tadalafil 20 mg alone. Although specific interactions have not been studied, other HIV protease inhibitors would likely increase tadalafil exposure [see Dosage and Administration (2.7)]. Depression.

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Unfortunately, Viagra is a medication known to cause quite a few side effects, some of them quite serious. What is encouraging, however, is the fact that most people suffer from only the least serious side effects of Sildenafil, which include flushing, nasal congestion, minor vision and metabolism impairments. Severe side effects are observed in extremely rare cases and may include heart attack or stroke, sudden hearing loss, priapism and arrhythmia. If you experience any symptoms of the latter after taking Viagra, seek emergency medical assistance immediately.Do not take Viagra if the packaging is torn or shows signs of tampering, or does not look quite right even if the tablets may look alright.

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