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Preclinical studies showed an additive systemic blood pressure lowering effect when PDE5 inhibitors were combined with riociguat. In clinical studies, riociguat has been shown to augment the hypotensive effects of PDE5 inhibitors. There was no evidence of favourable clinical effect of the combination in the population studied. Concomitant use of riociguat with PDE5 inhibitors, including tadalafil, is contraindicated (see section 4.3). levitra vs viagra
The HPFS began in 1986 when 51?529 US male health professionals, aged 40 to 75 years, completed a baseline questionnaire on medical history and lifestyle practices. Health professionals are highly motivated and committed to participating in this long-term project and appreciate the accuracy of reports, given their knowledge and medical background. Biennially, participants received a questionnaire, and a response rate exceeding 90% has been achieved in the follow-up. The study was approved by the Human Research Committee at Brigham and Women’s Hospital, Boston, Massachusetts. Participants’ completion and return of the questionnaire was considered informed consent.
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